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Article

Pharmacodynamics of early, high-dose linezolid against vancomycin-resistant enterococci with elevated MICs and pre-existing genetic mutations.

The Journal of antimicrobial chemotherapy - 1 Sept 2012

Tsuji Brian T, Bulitta Jurgen B, Brown Tanya, Forrest Alan, Kelchlin Pamela A, Holden Patty N, Peloquin Charles A, Skerlos Laura, Hanna Debra

Abstract excerpt

OBJECTIVES: Vancomycin-resistant enterococci (VRE) have emerged as an important nosocomial pathogen in medical centres worldwide. This study evaluated the impact of front-loading of linezolid on bacterial killing and suppression of resistance against VRE strains with defined genetic mutations. METHODS: Time-killing experiments over 48 h assessed the concentration effect relationship of linezolid against eight...

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PMID: 22685161
DOI: 10.1093/jac/dks201

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