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Article

Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to linezolid in an in vitro dynamic model.

The Journal of antimicrobial chemotherapy - 1 Nov 2017

Firsov Alexander A, Alieva Kamilla N, Strukova Elena N, Golikova Maria V, Portnoy Yury A, Dovzhenko Svetlana A, Kobrin Mikhail B, Romanov Andrey V, Edelstein Mikhail V, Zinner Stephen H

Abstract excerpt

OBJECTIVES: To test the mutant selection window (MSW) hypothesis applied to linezolid-exposed Staphylococcus aureus and to delineate the concentration-resistance relationship, a mixed inoculum of linezolid-susceptible S. aureus cells and linezolid-resistant mutants (RMs) was exposed to linezolid multiple dosing. METHODS: Three S. aureus strains (MIC of linezolid 2 mg/L), S. aureus 479, S. aureus 688 and S. aureus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28981793
DOI: 10.1093/jac/dkx249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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