Dose-related selection of fluoroquinolone-resistant Escherichia coli.

doi:10.1093/jac/dkm265

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Dose-related selection of fluoroquinolone-resistant Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Oct 2007

Olofsson Sara K, Marcusson Linda L, Strömbäck Ann, Hughes Diarmaid, Cars Otto

Abstract excerpt

OBJECTIVES: To investigate the effects of clinically used doses of norfloxacin, ciprofloxacin and moxifloxacin on survival and selection in Escherichia coli populations containing fluoroquinolone-resistant subpopulations and to measure the value of the pharmacodynamic index AUC/mutant prevention concentration (MPC) that prevents the growth of pre-existing resistant mutants. METHODS: Mixed cultures of susceptible...

Topics

Anti-Bacterial Agents
Colony Count, Microbial
Drug Resistance, Bacterial
Escherichia coli
Fluoroquinolones
Microbial Sensitivity Tests
Models, Biological
Mutation
Patient Selection

Source

Open in PubMed

Identifiers

PMID: 17635875
DOI: 10.1093/jac/dkm265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics