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Article

Dose-related selection of fluoroquinolone-resistant Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Oct 2007

Olofsson Sara K, Marcusson Linda L, Strömbäck Ann, Hughes Diarmaid, Cars Otto

Abstract excerpt

OBJECTIVES: To investigate the effects of clinically used doses of norfloxacin, ciprofloxacin and moxifloxacin on survival and selection in Escherichia coli populations containing fluoroquinolone-resistant subpopulations and to measure the value of the pharmacodynamic index AUC/mutant prevention concentration (MPC) that prevents the growth of pre-existing resistant mutants. METHODS: Mixed cultures of susceptible...

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Source

Identifiers

PMID: 17635875
DOI: 10.1093/jac/dkm265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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