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Article

Comparative genomics of xenobiotic metabolism: a porcine-human PXR gene comparison.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2007

Pollock Callie B, Rogatcheva Margarita B, Schook Lawrence B

Abstract excerpt

The pregnane X receptor (PXR) plays a crucial role in xenobiotic and drug metabolism, being the major transcriptional regulator of cytochrome P-450 monooxygenase 3A4, which metabolizes more than 50% of all clinically used drugs. Recent pharmacodynamic studies have shown that the mouse is not an ideal model for predicting human clinical drug study outcomes. Therefore, we characterized the porcine PXR (pPXR) gene...

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PMID: 17436120
DOI: 10.1007/s00335-007-9007-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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