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The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

1 Jan 2000

Abstract excerpt

Transcription of genes encoding cytochrome P450 3A (CYP3A) monooxygenases is induced by a variety of xenobiotics and natural steroids. There are marked differences in the compounds that induce CYP3A gene expression between species. Recently, the mouse and human pregnane X receptor (PXR) were shown to be activated by compounds that induce CYP3A expression. However, most studies of CYP3A regulation have been...

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Identifiers

PMID: 10628745
DOI: 10.1210/mend.14.1.0409

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