Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PXR: More Than Just a Master Xenobiotic Receptor

7 Nov 2017

Abstract excerpt

Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic receptor that coordinately regulates the expression of genes encoding drug-metabolizing enzymes and drug transporters to essentially detoxify and eliminate xenobiotics and endotoxins from the body. In the past several years, the function of PXR in the regulation of xenobiotic metabolism has been extensively studied, and the role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Estrogen and related hormone effects
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29113993
DOI: 10.1124/mol.117.110155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PXR: More Than Just a Master Xenobiotic ReceptorPMID 29113993Read ↗

The Nuclear Xenobiotic Receptor Pregnane X Receptor: Recent Insights and New ChallengesSemantic proximity Read ↗

PXR: A Xenobiotic Receptor of Diverse Function Implicated in PharmacogeneticsSemantic proximity Read ↗

Mechanisms and Therapeutic Advances of PXR in Metabolic Diseases and CancerSemantic proximity Read ↗

Pregnane X Receptor as the “Sensor and Effector” in Regulating EpigenomeSemantic proximity Read ↗

Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and DiseaseSemantic proximity Read ↗

Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 SuperfamilySemantic proximity Read ↗

Structure and Function of the Human Nuclear Xenobiotic Receptor PXRSemantic proximity Read ↗

Regulation of CAR and PXR Expression in Health and DiseaseSemantic proximity Read ↗

The Interface between Cell Signaling Pathways and Pregnane X ReceptorSemantic proximity Read ↗

Role of nuclear receptor PXR in immune cells and inflammatory diseasesSemantic proximity Read ↗

Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistanceSemantic proximity Read ↗

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during EvolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.