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Article

Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and Disease

1 Feb 2013

Abstract excerpt

Pregnane X Receptor (PXR), a member of the nuclear receptor (NR) superfamily, is expressed in liver and intestine, as also in other tissues and cells. PXR is activated by a wide variety of endobiotics, dietary compounds and pharmaceuticals. This nuclear receptor serves as a master transcriptional regulator of CYP3A isozymes, and also regulates a large number of enzymes and transporters involved in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 23237007
DOI: 10.2174/1389200211314030009

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