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The Nuclear Xenobiotic Receptor Pregnane X Receptor: Recent Insights and New Challenges

17 Jun 2005

Abstract excerpt

The nuclear receptor pregnane X receptor (PXR) plays a key but structurally enigmatic role in human biology. This ligand-regulated transcription factor responds to a diverse array of chemically distinct ligands, including many endogenous compounds and clinical drugs, and regulates the expression of a critical set of protective gene products involved in xenobiotic and endobiotic metabolism. The structural basis of...

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PMID: 15961506
DOI: 10.1210/me.2005-0156

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The Nuclear Xenobiotic Receptor Pregnane X Receptor: Recent Insights and New ChallengesPMID 15961506Read ↗

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