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Article

PXR: A Xenobiotic Receptor of Diverse Function Implicated in Pharmacogenetics

1 Nov 2008

Abstract excerpt

The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of drug-metabolic enzymes and transporters involved in the responses of mammals to their chemical environment. The same enzyme and transporter systems are also involved in the homeostasis of numerous endogenous chemicals. The regulatory function of PXR is implicated in normal physiology and diseases, such...

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PMID: 19018724
DOI: 10.2217/14622416.9.11.1695

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