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The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000-01-01

Abstract excerpt

Transcription of genes encoding cytochrome P450 3A (CYP3A) monooxygenases is induced by a variety of xenobiotics and natural steroids. There are marked differences in the compounds that induce CYP3A gene expression between species. Recently, the mouse and human pregnane X receptor (PXR) were shown to be activated by compounds that induce CYP3A expression. However, most studies of CYP3A regulation have been perform...

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Identifiers and source

Literature Corpus work
da64f8a1-9c17-56fb-a695-79cef462b71f
DOI
10.1210/me.14.1.27
Open publication

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The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during EvolutionDOI 10.1210/me.14.1.27
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