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Article

Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation.

The Journal of biological chemistry - 1 Jun 2007

Sakamoto Yasuo, Watanabe Sugiko, Ichimura Takaya, Kawasuji Michio, Koseki Haruhiko, Baba Hideo, Nakao Mitsuyoshi

Abstract excerpt

Methylated DNA binding domain (MBD) proteins and Polycomb group (PcG) proteins maintain epigenetic silencing of transcriptional activity. We report that the DNA methylation-mediated repressor MBD1 interacts with Ring1b and hPc2, the major components of Polycomb repressive complex 1. The cysteine-rich CXXC domains of MBD1 bound to Ring1b and the chromodomain of hPc2. Chromatin immunoprecipitation analysis revealed...

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Source

Identifiers

PMID: 17428788
DOI: 10.1074/jbc.M700011200

Genes

MBD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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