Article
A functionally conserved Polycomb response element from mouse HoxD complex responds to heterochromatin factors.
Scientific reports - 22 Oct 2013
Vasanthi Dasari, Nagabhushan A, Matharu Navneet Kaur, Mishra Rakesh K
Abstract excerpt
Anterior-posterior body axis in all bilaterians is determined by the Hox gene clusters that are activated in a spatio-temporal order. This expression pattern of Hox genes is established and maintained by regulatory mechanisms that involve higher order chromatin structure and Polycomb group (PcG) and trithorax group (trxG) proteins. We identified earlier a Polycomb response element (PRE) in the mouse HoxD complex...
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