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Article

Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2016

Tie Feng, Banerjee Rakhee, Fu Chen, Stratton Carl A, Fang Ming, Harte Peter J

Abstract excerpt

Drosophila Polycomb (PC), a subunit of Polycomb repressive complex 1 (PRC1), is well known for its role in maintaining repression of the homeotic genes and many others and for its binding to trimethylated histone H3 on Lys 27 (H3K27me3) via its chromodomain. Here, we identify a novel activity of PC: inhibition of the histone acetylation activity of CREB-binding protein (CBP). We show that PC and its mammalian CBX...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26802126
DOI: 10.1073/pnas.1515465113
PMCID: PMC4760827

Genes

PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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