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Article

Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.

The Journal of biological chemistry - 11 Aug 2006

Uchimura Yasuhiro, Ichimura Takaya, Uwada Junsuke, Tachibana Taro, Sugahara Satoko, Nakao Mitsuyoshi, Saitoh Hisato

Abstract excerpt

Small ubiquitin-related modifiers, SUMO-2/3 and SUMO-1, are involved in gene regulation and nuclear structures. However, little is known about the roles of SUMO, in heterochromatin formation of mammalian cells. Here we demonstrate that SUMOs directly interact with human MCAF1, which forms complexes with either the methyl-CpG-binding protein MBD1 or SETDB1, which trimethylates histone H3 at lysine 9 (H3-K9) in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16757475
DOI: 10.1074/jbc.M602280200

Genes

MBD1
SETDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.PMID 16757475Read ↗

SUMOylation enhances DNA methyltransferase 1 activity.Semantic proximity Read ↗

Sumoylation of MDC1 is important for proper DNA damage response.Semantic proximity Read ↗

SUMO Modification Enhances p66-Mediated Transcriptional Repression of the Mi-2/NuRD ComplexSemantic proximity Read ↗

Activation of the SUMO modification system is required for the accumulation of RAD51 at sites containing DNA damageSemantic proximity Read ↗

DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.Semantic proximity Read ↗

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SUMOylation differentially regulates SMCHD1 complex formation and function in a genomic context-specific mannerSemantic proximity Read ↗

Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation.Semantic proximity Read ↗

CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.Semantic proximity Read ↗

SUMO targets the APC/C to regulate transition from metaphase to anaphaseSemantic proximity Read ↗

RNF4 is required for DNA double-strand break repair in vivo.Semantic proximity Read ↗

Stability and DNA Methyltransferase Activity of DNMT3A are Maintained by Ubiquitin-Specific Peptidase 11 (USP11) and Sumoylation Countering DegradationSemantic proximity Read ↗

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