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Article

In vivo selection for metastasis promoting genes in the mouse

9 Apr 2007

Abstract excerpt

Here, we report the identification of a metastasis promoting factor by a forward genetic screen in mice. A retroviral cDNA library was introduced into the nonmetastatic cancer cell line 168FARN, which was then orthotopically transplanted into mouse mammary fat pads, followed by selection for cells that metastasize to the lung. The genes encoding the disulfide isomerase ERp5 and beta-catenin were found to promote...

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PMID: 17420453
DOI: 10.1073/pnas.0701145104

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