Article
Isolation of a novel mouse gene, mSVS-1/SUSD2, reversing tumorigenic phenotypes of cancer cells in vitro.
Cancer science - 1 Jun 2007
Sugahara Tetsuo, Yamashita Yzumi, Shinomi Masahito, Yamanoha Banri, Iseki Hiroyoshi, Takeda Akihiko, Okazaki Yasushi, Hayashizaki Yoshihide, Kawai Kenji, Suemizu Hiroshi, Andoh Toshiwo
Abstract excerpt
We report isolation of a novel tumor-reversing gene, tentatively named SVS-1, encoding a protein of 820 amino acids with localization on the plasma membrane as a type I transmembrane protein. The gene was found among those downregulated in the activated oncogene-v-K-ras-transformed NIH3T3 cells, Ki3T3, with tumorigenic phenotype. SVS-1 protein harbors several functional domains inherent to adhesion molecules....
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