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Identification of Smyd4 as a Potential Tumor Suppressor Gene Involved in Breast Cancer Development

21 Apr 2009

Abstract excerpt

To identify genes involved in breast tumorigenesis, we applied the retroviral LoxP-Cre system to a nontumorigenic mouse mammary epithelial cell line NOG8 to create random chromosome deletion/translocation. We found that the disruption of one allele of Smyd4 (SET and MYND domain containing 4) gene through chromosome translocation led to tumorigenesis. The expression of Smyd4 was markedly decreased in tumor cells....

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PMID: 19383909
DOI: 10.1158/0008-5472.can-08-4097

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