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Article

In vivo modeling of the EGFR family in breast cancer progression and therapeutic approaches.

Advances in cancer research - 1 Jan 2020

Simond Alexandra M, Muller William J

Abstract excerpt

Modeling breast cancer through the generation of genetically engineered mouse models (GEMMs) has become the gold standard in the study of human breast cancer. Notably, the in vivo modeling of the epidermal growth factor receptor (EGFR) family has been key to the development of therapeutics and has helped better understand the signaling pathways involved in cancer initiation, progression and metastasis. The...

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PMID: 32593401
DOI: 10.1016/bs.acr.2020.04.004

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