Gene expression patterns associated with the metastatic phenotype in rodent and human tumors.

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Article

Gene expression patterns associated with the metastatic phenotype in rodent and human tumors.

Cancer research - 15 Feb 2001

Nestl A, Von Stein O D, Zatloukal K, Thies W G, Herrlich P, Hofmann M, Sleeman J P

Abstract excerpt

Using subtractive technology, we have generated metastasis-associated gene expression profiles for rat mammary and pancreatic adenocarcinomas. Several genes whose expression is thought to be related to tumor progression such as c-Met, urokinase-type plasminogen activator receptor, ezrin, HMG-1, oncomodulin, cathepsin, and caveolin were thereby isolated. Half of the metastasis-associated clones showed no...

Topics

Animals
Cloning, Molecular
DNA, Complementary
DNA, Neoplasm
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
In Situ Hybridization
Neoplasm Metastasis
Neoplasms
Neoplasms, Experimental
Phenotype
Rats
Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 11245467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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