Article
Differentially expressed genes associated with the metastatic phenotype in breast cancer.
Breast cancer research and treatment - 1 May 1999
Kirschmann D A, Seftor E A, Nieva D R, Mariano E A, Hendrix M J
Abstract excerpt
We have previously shown that human breast carcinoma cells demonstrating an interconverted phenotype, where keratin (epithelial marker) and vimentin (mesenchymal marker) intermediate filaments are both expressed, have an increased ability to invade a basement membrane matrix in vitro. This increase in invasive potential has been demonstrated in MDA-MB-231 cells, which constitutively express keratins and vimentin,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.