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Article

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells.

Journal of visualized experiments : JoVE - 25 Aug 2021

Longo Jody Fromm, Brosius Stephanie N, Carroll Steven L

Abstract excerpt

The development of new drugs that precisely target key proteins in human cancers is fundamentally altering cancer therapeutics. However, before these drugs can be used, their target proteins must be validated as therapeutic targets in specific cancer types. This validation is often performed by knocking out the gene encoding the candidate therapeutic target in a genetically engineered mouse (GEM) model of cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34515675
DOI: 10.3791/62740
PMCID: PMC9286026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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