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Article

PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation.

Neuroscience research - 1 Jul 2007

Pletnikov Mikhail V, Xu Yanqun, Ovanesov Mikhail V, Kamiya Atsushi, Sawa Akira, Ross Christopher A

Abstract excerpt

A balanced chromosomal translocation, segregating with mental illnesses in a large Scottish family, interrupts the disrupted-in-schizophrenia 1 (DISC1) gene, which would result in loss of DISC1 function via haploinsufficiency or dominant-negative effects (or possibly could cause gain-of-function...

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Source

Identifiers

PMID: 17418909
DOI: 10.1016/j.neures.2007.03.003

Genes

DISC1
NGF
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17418909-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation.PMID 17418909Read ↗

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