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DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.

Human molecular genetics - 15 Nov 2006

Kamiya Atsushi, Tomoda Toshifumi, Chang Jennifer, Takaki Manabu, Zhan Caixin, Morita Masahiko, Cascio Matthew B, Elashvili Sarah, Koizumi Hiroyuki, Takanezawa Yasukazu, Dickerson Faith, Yolken Robert, Arai Hiroyuki, Sawa Akira

Abstract excerpt

Disrupted-In-Schizophrenia-1 (DISC1) is a unique susceptibility gene for major mental conditions, because of the segregation of its genetic variant with hereditary psychosis in a Scottish pedigree. Genetic association studies reproducibly suggest involvement of DISC1 in both schizophrenia and bipolar disorder in several ethnic groups. The DISC1 protein is multifunctional, and a pool of DISC1 in the dynein motor...

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Carrier Proteins
Exons
Nerve Tissue Proteins
Neurites
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17035248
DOI: 10.1093/hmg/ddl407

Genes

DISC1
NDEL1

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DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.PMID 17035248Read ↗

Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowthSemantic proximity Read ↗

Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.Semantic proximity Read ↗

Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.Semantic proximity Read ↗

Understanding the role of DISC1 in psychiatric disease and during normal development.Semantic proximity Read ↗

DISCopathies: brain disorders related to DISC1 dysfunction.Semantic proximity Read ↗

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding.Semantic proximity Read ↗

Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings.Semantic proximity Read ↗

Molecular mechanism of schizophrenia with reference to disrupted-in-schizophrenia 1 (DISC1).Semantic proximity Read ↗

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.Semantic proximity Read ↗

The DISC locus in psychiatric illness.Semantic proximity Read ↗

Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.Semantic proximity Read ↗

What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology?Semantic proximity Read ↗

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