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Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

20 Aug 2015

Abstract excerpt

Genetic and clinical association studies have identified disrupted in schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family in which the translocation predisposes to psychiatric disorders. We investigate the consequences of DISC1 interruption in human neural cells using TALENs or CRISPR-Cas9 to target the DISC1...

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PMID: 26299970
DOI: 10.1016/j.celrep.2015.07.061

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