Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes.

doi:10.1016/j.schres.2011.04.021

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Article

Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes.

Schizophrenia research - 1 Aug 2011

Katsel Pavel, Tan Weilun, Abazyan Bagrat, Davis Kenneth L, Ross Christopher, Pletnikov Mikhail V, Haroutunian Vahram

Abstract excerpt

Abnormalities in oligodendrocyte (OLG) differentiation and OLG gene expression deficit have been described in schizophrenia (SZ). Recent studies revealed a critical requirement for Disrupted-in-Schizophrenia 1 (DISC1) in neural development. Transgenic mice with forebrain restricted expression of mutant human DISC1 (ΔhDISC1) are characterized by neuroanatomical and behavioral abnormalities reminiscent of some...

Topics

Animals
Animals, Newborn
Brain
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Cell Cycle Proteins
Cell Differentiation
Doxycycline
Embryo, Mammalian
Female
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mice

Mice, Transgenic

Mutation

Myelin-Associated Glycoprotein

Nerve Tissue Proteins

Oligodendroglia

Phosphoric Diester Hydrolases

Source

Open in PubMed Open full text

Identifiers

PMID: 21605958
DOI: 10.1016/j.schres.2011.04.021
PMCID: PMC3139741

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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