Article
Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.
Molecular psychiatry - 1 Feb 2008
Pletnikov M V, Ayhan Y, Nikolskaia O, Xu Y, Ovanesov M V, Huang H, Mori S, Moran T H, Ross C A
Abstract excerpt
A strong candidate gene for schizophrenia and major mental disorders, disrupted-in-schizophrenia 1 (DISC1) was first described in a large Scottish family in which a balanced chromosomal translocation segregates with schizophrenia and other psychiatric illnesses. The translocation mutation may result in loss of DISC1 function via haploinsufficiency or dominant-negative effects of a predicted mutant DISC1 truncated...
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