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Article

Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone.

Endocrinology - 1 Jul 2007

Dvorak Melita M, Chen Tsui-Hua, Orwoll Benjamin, Garvey Caitlin, Chang Wenhan, Bikle Daniel D, Shoback Dolores M

Abstract excerpt

Changes in extracellular [Ca2+] modulate the function of bone cells in vitro via the extracellular Ca2+-sensing receptor (CaR). Within bone microenvironments, resorption increases extracellular [Ca2+] locally. To determine whether enhanced CaR signaling could modulate remodeling and thereby bone mass in vivo, we generated transgenic mice with a constitutively active mutant CaR (Act-CaR) targeted to their mature...

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Source

Identifiers

PMID: 17412806
DOI: 10.1210/en.2007-0147

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PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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