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Article

The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.

The Journal of clinical investigation - 1 Apr 2003

Kos Claudine H, Karaplis Andrew C, Peng Ji-Bin, Hediger Matthias A, Goltzman David, Mohammad Khalid S, Guise Theresa A, Pollak Martin R

Abstract excerpt

The extracellular calcium-sensing receptor (CaR; alternate gene names, CaR or Casr) is a membrane-spanning G protein-coupled receptor. CaR is highly expressed in the parathyroid gland, and is activated by extracellular calcium (Ca(2+)(o)). Mice homozygous for null mutations in the CaR gene (CaR(-/-)) die shortly after birth because of the effects of severe hyperparathyroidism and hypercalcemia. A wide variety of...

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Identifiers

PMID: 12671051
DOI: 10.1172/JCI17416
PMCID: PMC152589

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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