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Article

Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype.

Endocrinology - 1 Sept 2001

Garner S C, Pi M, Tu Q, Quarles L D

Abstract excerpt

The hypothesis that local changes in extracellular calcium may serve a physiological role in regulating osteoblast, osteoclast, and cartilage function through the extracellular cation-sensing receptor, CasR, is gaining widespread support, but lacks definite proof. To examine the effects of CasR deficiency on the skeleton, we performed a detailed analysis of the skeleton in CasR knockout mice (CasR(-/-)) and...

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Source

Identifiers

PMID: 11517179
DOI: 10.1210/endo.142.9.8364

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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