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Article

Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function.

Endocrinology - 1 Jul 2012

Bassett J H Duncan, Logan John G, Boyde Alan, Cheung Moira S, Evans Holly, Croucher Peter, Sun Xiao-yang, Xu Sai, Murata Yoshiharu, Williams Graham R

Abstract excerpt

Calcineurin-nuclear factor of activated T cells signaling controls the differentiation and function of osteoclasts and osteoblasts, and regulator of calcineurin-2 (Rcan2) is a physiological inhibitor of this pathway. Rcan2 expression is regulated by T(3), which also has a central role in skeletal development and bone turnover. To investigate the role of Rcan2 in bone development and maintenance, we characterized...

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PMID: 22593270
DOI: 10.1210/en.2011-1814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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