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Article

Structural and functional basis of amino acid specificity in the invertebrate cotransporter KAAT1.

The Journal of physiology - 15 Jun 2007

Miszner Andreea, Peres Antonio, Castagna Michela, Bettè Sara, Giovannardi Stefano, Cherubino Francesca, Bossi Elena

Abstract excerpt

The substrate specificity of KAAT1, a Na+- and K+-dependent neutral amino acid cotransporter cloned from the larva of the invertebrate Manduca sexta and belonging to the SLC6A gene family has been investigated using electrophysiological and radiotracer methods. The specificity of KAAT1 was compared to that of CAATCH1, a strictly related transporter with different amino acid selectivity. Competition experiments...

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Share to Amino Acid Transport Systems, Neutral
Share to Binding, Competitive

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leucine

Share to Manduca

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Share to Sodium

Share to Threonine

Share to Xenopus laevis

Source

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Identifiers

PMID: 17412764
DOI: 10.1113/jphysiol.2007.132555
PMCID: PMC2170845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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