Article
Aspartate 338 contributes to the cationic specificity and to driver-amino acid coupling in the insect cotransporter KAAT1.
Cellular and molecular life sciences : CMLS - 1 Jan 2004
Mari S A, Soragna A, Castagna M, Bossi E, Peres A, Sacchi V F
Abstract excerpt
To investigate the peculiar ionic specificity of KAAT1, an Na+- and K+-coupled amino acid cotransporter from Lepidoptera, a detailed analysis of membrane topology predictions was performed, together with sequence comparison with strictly Na+-dependent mammalian cotransporters from the same family. The analysis identified aspartate 338, a residue present also in the other cotransporter accepting K+ (CAATCH1), but...
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