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Article

Novel dicarboxylate selectivity in an insect glutamate transporter homolog.

PloS one - 1 Jan 2013

Wang Hui, Rascoe Avi M, Holley David C, Gouaux Eric, Kavanaugh Michael P

Abstract excerpt

Mammals express seven transporters from the SLC1 (solute carrier 1) gene family, including five acidic amino acid transporters (EAAT1-5) and two neutral amino acid transporters (ASCT1-2). In contrast, insects of the order Diptera possess only two SLC1 genes. In this work we show that in the mosquito Culex quinquefasciatus, a carrier of West Nile virus, one of its two SLC1 EAAT-like genes encodes a transporter...

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PMID: 23951049
DOI: 10.1371/journal.pone.0070947
PMCID: PMC3737229

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