Article
A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2).
The Journal of biological chemistry - 11 Sept 2009
Zhang Zhou, Albers Thomas, Fiumera Heather L, Gameiro Armanda, Grewer Christof
Abstract excerpt
The SLC38 family of solute transporters mediates the coupled transport of amino acids and Na(+) into or out of cells. The structural basis for this coupled transport process is not known. Here, a profile-based sequence analysis approach was used, predicting a distant relationship with the SLC5/6 transporter families. Homology models using the LeuT(Aa) and Mhp1 transporters of known structure as templates were...
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