Article
Role of a conserved glycine triplet in the NSS amino acid transporter KAAT1.
Biochimica et biophysica acta - 1 Jul 2012
Giovanola M, D'Antoni F, Santacroce M, Mari S A, Cherubino F, Bossi E, Sacchi V F, Castagna M
Abstract excerpt
K+-coupled amino acid transporter 1 (KAAT1) belongs to the NSS family of solute transporters and it is expressed in the midgut and in salivary glands of Manduca sexta larvae. As more than 80% of family members, KAATI shows a stretch of three glycines (G85-G87) that according to the structure of the prototype transporter LeuT, is located close to the access of the permeation pathway. In this work the role of the...
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