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Article

Role of a conserved glycine triplet in the NSS amino acid transporter KAAT1.

Biochimica et biophysica acta - 1 Jul 2012

Giovanola M, D'Antoni F, Santacroce M, Mari S A, Cherubino F, Bossi E, Sacchi V F, Castagna M

Abstract excerpt

K+-coupled amino acid transporter 1 (KAAT1) belongs to the NSS family of solute transporters and it is expressed in the midgut and in salivary glands of Manduca sexta larvae. As more than 80% of family members, KAATI shows a stretch of three glycines (G85-G87) that according to the structure of the prototype transporter LeuT, is located close to the access of the permeation pathway. In this work the role of the...

Topics

Alanine
Amino Acid Sequence
Amino Acid Substitution
Amino Acid Transport Systems, Neutral
Amino Acids
Animals
Biological Transport
Conserved Sequence
Dose-Response Relationship, Drug
Glycine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insect Proteins

Lithium

Manduca

Membrane Potentials

Mutation

Oocytes

Potassium

Sequence Homology, Amino Acid

Source

Identifiers

PMID: 22402268
DOI: 10.1016/j.bbamem.2012.02.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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