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Article

A single residue in transmembrane domain 11 defines the different affinity for thiazides between the mammalian and flounder NaCl transporters.

American journal of physiology. Renal physiology - 1 Nov 2010

Castañeda-Bueno María, Vázquez Norma, Bustos-Jaimes Ismael, Hernández Damian, Rodríguez-Lobato Erika, Pacheco-Alvarez Diana, Cariño-Cortés Raquel, Moreno Erika, Bobadilla Norma A, Gamba Gerardo

Abstract excerpt

Little is known about the residues that control the binding and affinity of thiazide-type diuretics for their protein target, the renal Na(+)-Cl(-) cotransporter (NCC). Previous studies from our group have shown that affinity for thiazides is higher in rat (rNCC) than in flounder (flNCC) and that the transmembrane region (TM) 8-12 contains the residues that produce this difference. Here, an alignment analysis of...

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Identifiers

PMID: 20719978
DOI: 10.1152/ajprenal.00412.2010
PMCID: PMC2980407

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