Article
Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids.
Molecular and cellular endocrinology - 5 Mar 2017
Hinz Katrin M, Neef Dominik, Rutz Claudia, Furkert Jens, Köhrle Josef, Schülein Ralf, Krause Gerd
Abstract excerpt
The L-type amino acid transporter 2 (LAT2) imports amino acids (AA) and also certain thyroid hormones (TH), e.g. 3,3'-T2 and T3, but not rT3 and T4. We utilized LAT2 mutations (Y130A, N133S, F242W) that increase 3,3'-T2 import and focus here on import and export capacity for AA, T4, T3, BCH and derivatives thereof to delineate molecular features. Transport studies and analysis of competitive inhibition of import...
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