Article

U5 snRNA interactions with exons ensure splicing precision

2021-03-08

Abstract excerpt

Imperfect conservation of human pre-mRNA splice sites is necessary to produce alternative isoforms. This flexibility is combined with precision of the message reading frame. Apart from intron-termini GU_AG and the branchpoint A, the most conserved are the exon-end guanine and +5G of the intron-start. Association between these guanines cannot be explained solely by base-pairing with U1snRNA in the early spliceosome...

Identifiers and source

Literature Corpus work: cd8f693e-1b26-5ca8-afda-7ae0cf2f37f5
DOI: 10.1101/2021.03.07.434243

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