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Article

Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element.

Genes & development - 1 Dec 1991

Zavanelli M I, Ares M

Abstract excerpt

To understand the role of U2 RNA structure in pre-mRNA splicing we have characterized several cold-sensitive mutations in an essential stem-loop of yeast U2. Although mutant U2 is stable in vivo after a shift to restrictive temperature, splicing is rapidly inhibited, suggesting a direct effect on U2 function rather than U2 synthesis or snRNP assembly. Splicing complexes form at 23 degrees C in both mutant and...

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Identifiers

PMID: 1752442
DOI: 10.1101/gad.5.12b.2521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element.PMID 1752442Read ↗

Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.Semantic proximity Read ↗

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The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Semantic proximity Read ↗

Genomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF.Semantic proximity Read ↗

A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing.Semantic proximity Read ↗

Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome.Semantic proximity Read ↗

Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.Semantic proximity Read ↗

Functionally redundant interactions between U2 and U6 spliceosomal snRNAs.Semantic proximity Read ↗

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PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels.Semantic proximity Read ↗

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