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Article

Remodeling of U2-U6 snRNA helix I during pre-mRNA splicing by Prp16 and the NineTeen Complex protein Cwc2.

Nucleic acids research - 1 Jul 2014

Hogg Rebecca, de Almeida Rogerio Alves, Ruckshanthi Jayalath P D, O'Keefe Raymond T

Abstract excerpt

Removal of intron regions from pre-messenger RNA (pre-mRNA) requires spliceosome assembly with pre-mRNA, then subsequent spliceosome remodeling to allow activation for the two steps of intron removal. Spliceosome remodeling is carried out through the action of DExD/H-box ATPases that modulate RNA-RNA and protein-RNA interactions. The ATPase Prp16 remodels the spliceosome between the first and second steps of...

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Identifiers

PMID: 24848011
DOI: 10.1093/nar/gku431
PMCID: PMC4081067

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Remodeling of U2-U6 snRNA helix I during pre-mRNA splicing by Prp16 and the NineTeen Complex protein Cwc2.PMID 24848011Read ↗

The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing.Semantic proximity Read ↗

Characterization of Cwc2, U6 snRNA, and Prp8 interactions destabilized by Prp16 ATPase at the transition between the first and second steps of splicing.Semantic proximity Read ↗

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing.Semantic proximity Read ↗

The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing.Semantic proximity Read ↗

Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.Semantic proximity Read ↗

The Prp19C subunits Cwc15 and Syf2 function in TREX occupancy and transcription elongationSemantic proximity Read ↗

Cwf16p Associating with the Nineteen Complex Ensures Ordered Exon Joining in Constitutive Pre-mRNA Splicing in Fission Yeast.Semantic proximity Read ↗

CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.Semantic proximity Read ↗

Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps.Semantic proximity Read ↗

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing.Semantic proximity Read ↗

Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

Splicing quality control mediated by DHX15 and its G-patch activator, SUGP1Semantic proximity Read ↗

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