Article
Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.
Human molecular genetics - 15 Mar 2007
Cunninghame Graham Deborah S, Manku Harinder, Wagner Susanne, Reid Julia, Timms Kirsten, Gutin Alexander, Lanchbury Jerry S, Vyse Tim J
Abstract excerpt
Results from two studies have implicated the interferon regulatory gene IRF5 as a susceptibility gene in systemic lupus erythematosus (SLE). In this study, we conducted a family-based association analysis in 380 UK SLE nuclear families. Using a higher density of markers than has hitherto been screened, we show that there is association with two SNPs in the first intron, rs2004640 (P = 3.4 x 10(-4)) and rs3807306...
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