Article
Development of the "Inje cocktail" for high-throughput evaluation of five human cytochrome P450 isoforms in vivo.
Clinical pharmacology and therapeutics - 1 Nov 2007
Ryu J Y, Song I S, Sunwoo Y E, Shon J H, Liu K H, Cha I J, Shin J G
Abstract excerpt
To develop and validate an in vivo cocktail method for high-throughput phenotyping of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A, 12 healthy subjects received five probe drugs alone or simultaneously. The in vivo phenotyping index of CYP2C9, the ratio of 8 h urine concentration of losartan to its metabolite after a single administration of losartan, was not significantly different from that obtained using the...
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