Article
Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Clinical pharmacology and therapeutics - 1 Oct 2000
Streetman D S, Bleakley J F, Kim J S, Nafziger A N, Leeder J S, Gaedigk A, Gotschall R, Kearns G L, Bertino J S
Abstract excerpt
BACKGROUND: Simultaneous administration of several probes enhances the utility of phenotyping, but poor specificity, side effects, and use of drugs not approved by the Food and Drug Administration limit the usefulness of prior phenotyping cocktails. OBJECTIVES: To evaluate potential drug-drug interactions associated with use of a cocktail of caffeine, omeprazole, dextromethorphan, and midazolam for simultaneous...
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