Article
The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.
Clinical pharmacology and therapeutics - 1 Jun 2003
Christensen Magnus, Andersson Katarina, Dalén Per, Mirghani Rajaa A, Muirhead Gary J, Nordmark Anna, Tybring Gunnel, Wahlberg Anneli, Yaşar Umit, Bertilsson Leif
Abstract excerpt
OBJECTIVES: Our objectives were (1) to determine whether the drugs caffeine, losartan, omeprazole, debrisoquin (INN, debrisoquine), and quinine can be given simultaneously in low doses as a cocktail for the phenotyping of cytochrome P450 (CYP) 1A2, 2C9, 2C19, 2D6, and 3A4, respectively, and (2) to design an administration schedule to give as few sampling occasions as possible. METHODS: Twenty-four subjects were...
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