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Article

An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 1 Mar 2020

Eagles Shane K, Wang Xiaosuo, Gross Annette S, McLachlan Andrew J

Abstract excerpt

Measuring in vivo changes in the drug metabolizing activity of cytochrome P450 (CYP) enzymes is critical to understanding and assessing drug-drug, drug-diet and drug-disease interactions. The sensitivity and specificity of ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) makes it an ideal tool for analyzing drugs and their metabolites in biological matrices, and has demonstrated...

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PMID: 32050158
DOI: 10.1016/j.jchromb.2020.122013

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