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Article

A Phenotyping Tool for Seven Cytochrome P450 Enzymes and Two Transporters: Application to Examine the Effects of Clopidogrel and Gemfibrozil.

Clinical pharmacology and therapeutics - 1 Jun 2025

Aurinsalo Laura, Lapatto-Reiniluoto Outi, Kurkela Mika, Neuvonen Mikko, Kiiski Johanna I, Niemi Mikko, Tornio Aleksi, Backman Janne T

Abstract excerpt

Clinical cocktails for cytochrome P450 (CYP) phenotyping lack a marker for CYP2C8. We aimed to combine the CYP2C8 index drug repaglinide with the Geneva cocktail (caffeine/CYP1A2, bupropion/CYP2B6, flurbiprofen/CYP2C9, omeprazole/CYP2C19, dextromethorphan/CYP2D6, and midazolam/CYP3A4). We also included endogenous organic anion transporting polypeptide (OATP) 1B1 and 1B3 biomarkers glycochenodeoxycholate...

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Source

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Identifiers

PMID: 39982209
DOI: 10.1002/cpt.3610
PMCID: PMC12087695

Genes

CYP2C8
CYP1A2
CYP2B6
CYP2C19
CYP2C9
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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A Phenotyping Tool for Seven Cytochrome P450 Enzymes and Two Transporters: Application to Examine the Effects of Clopidogrel and Gemfibrozil.PMID 39982209Read ↗

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