Article
Can a cocktail designed for phenotyping pharmacokinetics and metabolism enzymes in human be used efficiently in rat?
Xenobiotica; the fate of foreign compounds in biological systems - 1 Apr 2012
Videau Orianne, Pitarque Sylvain, Troncale Sylvie, Hery Patrick, Thévenot Etienne, Delaforge Marcel, Bénech Henri
Abstract excerpt
We recently designed the CIME cocktail consisting of 10 drugs to assess the activity of the major human CYPs (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A), a phase II enzyme (UGT1A1/6/9), two drug transporters (P-gp and OATP1B1) and a component of the renal function ( Videau et al. 2010 ). The present work aimed at studying the usefulness of the CIME cocktail in the rat.The CIME cocktail was given per os to...
Topics
- Animals
- Cytochrome P-450 Enzyme System
- Female
- Humans
- Male
- Membrane Transport Proteins
- Pharmacokinetics
- Phenotype
- Rats
- Sex Factors
- Species Specificity
- Tandem Mass Spectrometry