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Article

A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes.

Journal of pharmaceutical and biomedical analysis - 3 Sept 2004

Jerdi Mallorie Clement, Daali Youssef, Oestreicher Mitsuko Kondo, Cherkaoui Samir, Dayer Pierre

Abstract excerpt

An efficient, fast and reliable analytical method was developed for the simultaneous evaluation of the activities of five major human drug metabolising cytochrome P450 (1A2, 2C9, 2C19, 2D6 and 3A4) with a cocktail approach including five probe substances, namely caffeine, flurbiprofen, omeprazole, dextromethorphan and midazolam. All substances were administered simultaneously and a single plasma sample was...

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Source

Identifiers

PMID: 15336365
DOI: 10.1016/j.jpba.2004.03.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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