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Article

A cytochrome P450 phenotyping cocktail causing unexpected adverse reactions in female volunteers.

European journal of clinical pharmacology - 1 Dec 2013

Pedersen Rasmus Steen, Damkier Per, Christensen Mette Marie Hougaard, Brosen Kim

Abstract excerpt

BACKGROUND: A four-drug cytochrome P450 (CYP) phenotyping cocktail was developed to rapidly and safely determine CYP2D6, CYP2C19, CYP2C9 and CYP1A2 enzyme activity and phenotype. METHODS: The cocktail consisted of the single CYP phenotyping probes of 50 mg tramadol (CYP2D6), 20 mg omeprazole (CYP2C19), 25 mg losartan (CYP2C9) and 200 mg caffeine (CYP1A2) and was administered as a single oral dose. For enzyme...

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PMID: 23917460
DOI: 10.1007/s00228-013-1561-1

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