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Article

Phenotyping of CYP450 in human liver microsomes using the cocktail approach.

Analytical and bioanalytical chemistry - 1 Aug 2014

Spaggiari Dany, Geiser Laurent, Daali Youssef, Rudaz Serge

Abstract excerpt

The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight CYP-specific probe substrates to simultaneously evaluate the activity of the most important CYPs, namely, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1,...

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Share to Chromatography, Liquid
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microsomes, Liver

Share to Mitochondria, Liver

Share to Spectrometry, Mass, Electrospray Ionization

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Identifiers

PMID: 24894520
DOI: 10.1007/s00216-014-7915-4

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